Kevin Lu
Kevin Lu

Kevin Lu

PhD student · Northeastern University
NSF GRFP Fellow

I'm a PhD student at Northeastern working on AI for biology, advised by David Bau and Wengong Jin. I use mechanistic interpretability to understand protein and cell foundation models, and I want to use what we learn to accelerate drug discovery.

Most recently, I've been reverse-engineering AI protein folding models (ESMFold, OpenFold, Boltz-1) to find out how they turn sequence chemistry into 3D structure.

Steering charge inside ESMFold
α = 0.00σ
Like charges repel. ESMFold linearly encodes residue charge. Steering both strands of a β-hairpin toward positive charge pushes them apart until the hairpin unzips. From Two Stages of Folding (NeurIPS 2026).

News

  • Sep 2026NeurIPSTwo Stages of Folding: Convergent Mechanisms in AI Protein Folding Trunks was accepted to NeurIPS 2026! The new version extends our ESMFold analysis to OpenFold and Boltz-1.
  • Feb 2026Presented our protein folding work at the Flatiron Institute.
  • Sep 2025NeurIPSWhen Are Concepts Erased From Diffusion Models? was accepted to the NeurIPS 2025 main track.
  • Jul 2025Started a 6-month internship at Takeda Pharmaceuticals on protein language model interpretability for antibody design.

Reviewing

Publications & Presentations

Projects